| Site | State | Type | Population |
|---|---|---|---|
| Sioux Falls, SD | South Dakota | City | 180927 |
| Siskiyou County , CA | California | County | 44118 |
| Skagit County, WA | Washington | County | 130696 |
| Skamania County, WA | Washington | County | 12170 |
| Skokie, IL | Illinois | City | 66422 |
| Slidell, LA | Louisiana | City | 28658 |
| Smith County, TX | Texas | County | 237186 |
| Smithfield Township, PA | Pennsylvania | City | 7481 |
| Snohomish County, WA | Washington | County | 833540 |
| Snyder County, PA | Pennsylvania | County | 39621 |
| Socorro, TX | Texas | City | 36236 |
| Solano County, CA | California | County | 451716 |
| Solon, OH | Ohio | City | 23929 |
| Somerset County, NJ | New Jersey | County | 345647 |
| Somerville, NJ | New Jersey | City | 12139 |
| Sonoma County, CA | California | County | 485887 |
| Sonora, KY | Kentucky | City | 566 |
| Soquel, CA | California | City | 10721 |
| South Bay, FL | Florida | City | 6665 |
| South Beloit, IL | Illinois | City | 7730 |
| South Bend, IN | Indiana | City | 103453 |
| South Burlington, VT | Vermont | City | 19141 |
| South Coatesville, PA | Pennsylvania | City | 1604 |
| South Fulton, GA | Georgia | City | 108575 |
| South Gate, CA | California | City | 91154 |
| South Hackensack, NJ | New Jersey | City | 2466 |
| South Hill, VA | Virginia | City | 4709 |
| South Jordan, UT | Utah | City | 80139 |
| South Middleton Township, PA | Pennsylvania | City | 15425 |
| South Point Village, OH | Ohio | City | 3772 |
| South Portland, ME | Maine | City | 25665 |
| South Salt Lake, UT | Utah | City | 26166 |
| South San Francisco, CA | California | City | 64251 |
| South Sioux City, NE | Nebraska | City | 12867 |
| South Tucson, AZ | Arizona | City | 4585 |
| Southampton, NY | New York | City | 58902 |
| Southaven, MS | Mississippi | City | 55429 |
| Southborough, MA | Massachusetts | City | 10169 |
| Southeast, NY | New York | City | 18085 |
| Southfield, MI | Michigan | City | 75898 |
| Southgate, MI | Michigan | City | 30047 |
| Southington, CT | Connecticut | City | 43807 |
| Southlake, TX | Texas | City | 31105 |
| Sparks, NV | Nevada | City | 109796 |
| Spartanburg County, SC | South Carolina | County | 313791 |
| Spartanburg, SC | South Carolina | City | 37448 |
| Spokane County, WA | Washington | County | 546050 |
| Spokane Valley, WA | Washington | City | 105905 |
| Spokane, WA | Washington | City | 229071 |
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