| Site | State | Type | Population |
|---|---|---|---|
| Sedona, AZ | Arizona | City | 9763 |
| Seekonk, MA | Massachusetts | City | 15702 |
| Seffner, FL | Florida | City | 8236 |
| Sellersburg, IN | Indiana | City | 9583 |
| Seminole County, FL | Florida | County | 471058 |
| Seminole, TX | Texas | City | 7026 |
| Seneca County, NY | New York | County | 33688 |
| Seneca, SC | South Carolina | City | 8900 |
| Severance, CO | Colorado | City | 5611 |
| Sevier County, TN | Tennessee | County | 98007 |
| Sevierville, TN | Tennessee | City | 17185 |
| Seward County, NE | Nebraska | County | 17603 |
| Sewickley, PA | Pennsylvania | City | 3800 |
| Seymour, IN | Indiana | City | 19780 |
| Shakopee, MN | Minnesota | City | 44547 |
| Shalersville Township, OH | Ohio | City | 5650 |
| Shallowater, TX | Texas | City | 2940 |
| Shamokin, PA | Pennsylvania | City | 7051 |
| Sharonville, OH | Ohio | City | 14659 |
| Shasta County, CA | California | County | 179276 |
| Shawano County, WI | Wisconsin | County | 40880 |
| Shawnee County, KS | Kansas | County | 178909 |
| Shawnee, KS | Kansas | City | 67511 |
| Sheboygan County, WI | Wisconsin | County | 117747 |
| Sheboygan Falls, WI | Wisconsin | City | 8165 |
| Sheboygan, WI | Wisconsin | City | 49931 |
| Shelburne, VT | Vermont | City | 6726 |
| Shelby County, AL | Alabama | County | 226902 |
| Shelby County, TN | Tennessee | County | 924454 |
| Shelby, NC | North Carolina | City | 20046 |
| Shelbyville, TN | Tennessee | City | 23743 |
| Shelton, CT | Connecticut | City | 41474 |
| Shenandoah County, VA | Virginia | County | 44752 |
| Shepherdsville, KY | Kentucky | City | 14328 |
| Sheridan, WY | Wyoming | City | 17938 |
| Sherman County, OR | Oregon | County | 1907 |
| Shirley, NY | New York | City | 25913 |
| Shoreline, WA | Washington | City | 57198 |
| Shoreview, MN | Minnesota | City | 26670 |
| Shorter, AL | Alabama | City | 352 |
| Shreveport, LA | Louisiana | City | 189890 |
| Sidney, NE | Nebraska | City | 6439 |
| Sidney, OH | Ohio | City | 20421 |
| Signal Hill, CA | California | City | 11563 |
| Siloam Springs, AR | Arkansas | City | 14480 |
| Silver Creek, GA | Georgia | City | 5898 |
| Simi Valley, CA | California | City | 125975 |
| Simpsonville, SC | South Carolina | City | 24685 |
| Sioux City, IA | Iowa | City | 85617 |
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