Greensboro is a city in northern North Carolina with a population of just under 300,000. Among the many documented problems associated with prostitution in the city has been the activity of two different serial murderers who specifically targeted local prostituted women in the 1990s. One sex trafficking incident of concern to the community involved the exploitation of three high school students under 16 years of age.

Among the tactics used to combat the local commercial sex market, the Greensboro Police Department has conducted street-level reverse stings to decrease the demand for prostitution.  The department fields many complaints from residents about prostitution, particularly on the streets and in the yards, driveways, and doorsteps of residents.  Police ask residents to contact them with detailed information about suspicious activity.

Loss of employment is another consequence of buying sex that has occurred within the city. For example, in August, 2019, a Greensboro police officer resigned three days before being charged with soliciting a prostituted woman. Also charged was the woman for engaging in prostitution. The man had joined the Greensboro Police Department in 2006, and last worked in the patrol division before resigning.  His identity was included in news reports.